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标题：Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R usepackage usepackage usepackage usepackage beginupgamma end γ null (NSG) mice
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作者：Do Hee Kwon ; Jae Berm Park ; Joo Sang Lee 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-90110-z
语种：English
出版社：Springer Nature
摘要：Human delta-like 1 (hDlk1) is known to be able to regulate cell fate decisions during hematopoiesis. Mesenchymal stromal cells (MSCs) are known to exhibit potent immunomodulatory roles in a variety of diseases. Herein, we investigated in vivo functions of hDlk1 -hMSCs and hDlk1 +hMSCs in T cell development and T cell response to viral infection in humanized NOD/SCID/IL-2Rγ null (NSG) mice. Co-injection of hDlk1 -hMSC with hCD34 + cord blood (CB) cells into the liver of NSG mice markedly suppressed the development of human T cells. In contrast, co-injection of hDlk1 +hMSC with hCD34 + CB cells into the liver of NSG dramatically promoted the development of human T cells. Human T cells developed in humanized NSG mice represent markedly diverse, functionally active, TCR V \documentclass[12pt