文章基本信息

标题：Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates
本地全文：下载
作者：Ulla B. Mogensen ; Philippe Grandjean ; Carsten Heilmann 等
期刊名称：Environmental Health - a Global Access Science Source
印刷版ISSN：1476-069X
电子版ISSN：1476-069X
出版年度：2015
卷号：14
期号：1
页码：47
DOI：10.1186/s12940-015-0032-9
语种：English
出版社：BioMed Central
摘要：Exposure to perfluorinated alkylate substances (PFASs) is associated with immune suppression in animal models, and serum concentrations of specific antibodies against certain childhood vaccines tend to decrease at higher exposures. As such, we investigated the immunotoxic impacts of the three major PFASs in a Faroese birth cohort. A total of 464 children contributed blood samples collected at age 7 years. PFAS concentrations and concentrations of antibodies against diphtheria and tetanus were assessed in serum at age 7 years, and results were available from samples collected at age 5. In addition to standard regressions, structural equation models were generated to determine the association between three major PFASs measured at the two points in time and the two antibody concentrations. Concentrations of all three 7-year PFAS concentrations were individually associated with a decrease in concentrations of antibodies, however, it was not possible to attribute causality to any single PFAS concentration. Hence, the three 7-year concentrations were combined and showed that a 2-fold increase in PFAS was associated with a decrease by 54.4 % (95 % CI: 22.0 %, 73.3 %) in the antibody concentration. If considering both the age-5 and age-7 concentrations of the three major PFASs, the exposure showed a slightly greater loss. These analyses strengthen the evidence of human PFAS immunotoxicity at current exposure levels and reflect the usefulness of structural equation models to adjust for imprecision in the exposure variables.
关键词：Structural Equation Model ; Antibody Concentration ; Standardize Root Mean Square Residual ; Booster Vaccination ; PFOA Concentration