文章基本信息

标题：INVESTIGATION OF HEPATOTOXIC EFFECT OF BRYOPHYTES (HOMALOTHECIUM SERICEUM (HEDW) SCHIMP.) ON RAT LIVER
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作者：Samil Ozturk ; Ozlem Tongue Yayintas
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2021
卷号：30
期号：2
页码：1134-1146
语种：English
出版社：PSP Publishing
摘要：No evidence has been found to determinewhether moss extract affects fibrotic,inflammatory,apoptotic and tissue homeostasis for tissue regenera-tion on rat's liver tissue.In our study,1 ml of dis-tilled water (Group I),and 50 mg/kg (Group II),100mg/kg (Group m),300 mg/kg (Group IV),500mg/kg (Group V) for 30 days’doses of moss and bygavage ofa total of 30 female rats in liver tissue dueto the increase in the dose of moss histopathologywas revealed.Also,immunohistochemical stainingwas performed to determine the immunoreactivity oftranscription factor nuclear factor Kappa-B (NF-KB),tumor necrosis factor ( TNF-α),which regulatesinflammation and immune response,and TUNEL(Terminal deoxynucleotidyl transferase dUTP nickend labeling) for the assessment of the apoptotic pro-cess.The stained tissue samples were evaluated withthe image analysis system under the research micro-scope and One-way ANOVA,Tukey test,which isone of the nonparametric tests,was used to deter-mine the differences between the groups statisticallyand the results were evaluated according to p≤0.05.we found that liver damage increased due to the in-creased dose of moss species used in the experiment.At the same time,antioxidant activity was increased,and apoptosis was increased.Considering these re-sults,it was concluded that algae extract would haveanticancer properties and could be used in the phar-maceutical industry.
关键词：lmmunohistochemistry;Apoptosis;TUNEL;TNF-a;NF-kB;Bryophytes