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标题：Hydra vulgaris shows stable responses to thermal stimulation despite large changes in the number of neurons
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作者：Constantine N. Tzouanas ; Soonyoung Kim ; Krishna N. Badhiwala 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：6
页码：1-23
DOI：10.1016/j.isci.2021.102490
语种：English
出版社：Elsevier
摘要：SummaryMany animals that lose neural tissue to injury or disease can maintain behavioral repertoires by regenerating new neurons or reorganizing existing neural circuits. However, most neuroscience small model organisms lack this high degree of neural plasticity. We show thatHydra vulgariscan maintain stable sensory-motor behaviors despite 2-fold changes in neuron count, due to naturally occurring size variation or surgical resection. Specifically, we find that both behavioral and neural responses to rapid temperature changes are maintained following these perturbations. We further describe possible mechanisms for the observed neural activity and argue thatHydra's radial symmetry may allow it to maintain stable behaviors when changes in the numbers of neurons do not selectively eliminate any specific neuronal cell type. These results suggest thatHydraprovides a powerful model for studying how animals maintain stable sensory-motor responses within dynamic neural circuits and may lead to the development of general principles for injury-tolerant neural architectures.Graphical abstractDisplay OmittedHighlights•Thermal stimulation drives temperature-dependent firing rate in specificHydraneurons•Hydrashow stable neural responses to temperature despite 2× decrease in neuron count•Injury tolerance ofHydraoffers model for stable neural architectureBehavioral neuroscience; Biological sciences; Developmental neuroscience; Neuroscience;