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标题：Vitamin D Deficiency is Associated with High Levels of LDL Cholesterol in NAFL Children
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作者：Antonellla Mosca ; Andrea Dello Strologo ; Mariateresa Sanseviero 等
期刊名称：General Internal Medicine and Clinical Innovations
电子版ISSN：2397-5237
出版年度：2019
卷号：4
期号：2
页码：1-5
DOI：10.15761-GIMCI.1000175
语种：English
出版社：Open Access Text
摘要：Background: The association between vitamin D deficiency and children with obesity with non-alcoholic fatty liver disease (NAFL) has been described in several studies, but little is known about the exact mechanism which links Vitamin D to dyslipidemia and fatty liver disease in pediatric population. Objective: Our aim of the present study was to investigate the relationship between Vitamin D (VD) serum levels and serum lipid profiles in a pediatric population with Non Alcoholic Fatty Liver Disease (NAFLD). Methods: We enrolled 155 pediatric patients diagnosed with NAFLD. Patients were divided into two groups on the basis of the presence/absence of Vit D deficiency (VD-/VD+). Anthropometric (weight, height, waist circumference and BMI), parameters, laboratory values (e.g. triacylglycerols, cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose, insulin resistance and Vitamin D levels) and radiological (liver ultrasound for steatosis) parameters were taken. Results: We found that BMI, blood pressure, TAG, LDL-C, insulin resistance and progressive liver steatosis were proportionally related to low VD serum levels. This showed that vitamin D deficiency may be associated with an increased risk of dyslipidemias: increase in serum of 10 ng/dL of VD was associated with decreases of 0.73 mg/dL in TAG and 0.98 mg/dL in LDL-C. Conclusion: Vitamin D deficiency can be considered as a marker for elevated atherogenic lipoproteins and liver fibrosis taking part in the progression of pediatric NAFLD.
关键词：NAFLD; children; Vitamin D; LDL-cholesterol; lipoproteins