文章基本信息

标题：Autologous bone marrow stem cell implantation in treatment of thromboangiitis obliterans
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作者：Ali İhsan Tekin ; Mehmet Erdem Memetoğlu ; Rasim Kutlu 等
期刊名称：General Internal Medicine and Clinical Innovations
电子版ISSN：2397-5237
出版年度：2016
卷号：1
期号：5
页码：79-82
DOI：10.15761-GIMCI.1000124
语种：English
出版社：Open Access Text
摘要：Objective: The aim of this study was to assess the effectiveness and safety of autologous bone marrow stem cell (ABMMNC) treatment in patients with thromboangiitis obliterans (TAO, Buerger’s disease). Materials and methods: In this prospective study, twenty-two male patients with TAO were treated with ABMMNC implantation. All patients were Class II and III according to Rutherford Classification with a mean age of 48.27 ± 11.55 years. The mean follow up period was 30 ± 22.12 (range 9-64) months. Control visits were at weeks 4, 12 and 24. At each control visit, collateralization scores with digital substrat angiography (DSA) or computerised tomography (CT) angiography, treadmill maximum walking distance test, ankle brachial pressure index (ABPI) measurement and visual analogue scale (VAS) evaluation were performed. Results: The treadmill painless walking distance test was found 272.27 ± 164.96 meter (m) before implantation, and 310 ± 172.54 m, six months after the ABMMNC implantation (p=0.003*, p Conclusion: The findings of this study suggest that ABMMNC implantation in the treatment of patients with TAO might be safe and effective option for treating ischaemic limbs.
关键词：thromboanjiitis obliterans; stem cell; neovascularisation; treatment