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标题：Influence of K2<-sub>EDTA, sodium citrate and lithium heparin anticoagulants on lipid profile in plasma samples as measured by an automated chemical analyzer
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作者：Enoch Odame Anto ; William Kwame Boakye Ansah Owiredu ; Christian Obirikorang 等
期刊名称：Biomedical Research and Clinical Practice
电子版ISSN：2397-9631
出版年度：2017
卷号：2
期号：5
页码：1-4
DOI：10.15761-BRCP.1000153
语种：English
出版社：Open Access Text
摘要：Introduction: The use of serum or plasma in clinical pathology remains controversial. Using gel separator tubes is time consuming and may not help in clinical analysis during emergency cases. We compared the effect of heparin, K2EDTA, sodium citrate anticoagulants to gel separator tubes on lipid profile.Methods: This cross-sectional study was conducted in Bekwai Government Hospital. A total number of 115 participants were recruited for this study. Fasting blood samples were collected from each patient into heparin, K2EDTA, sodium citrate and gel separator tubes simultaneously. Samples in anticoagulant tubes were immediately centrifuged and plasma was obtained while samples in gel separator tubes were made to clot before centrifugation to obtain serum. The plasma and serum obtained was used to estimate total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-c), and high-density lipoprotein (HDL-c) using an automated chemistry Analyser.Results: The mean levels of TC (p2EDTA the mean levels of TG (p>0.05) was not different but TC (p2EDTA and sodium citrate anticoagulant tube compared to gel separator tubes (p>0.05).Conclusion: K2EDTA anticoagulant tubes may not have significant changes in TG levels. Heparin, K2EDTA and sodium citrate anticoagulant tubes may serve as substitute for gel separator tube for HDL-c analysis in emergency cases.
关键词：anticoagulants;gel separator;heparin;K2EDTA;lipoprotein; sodium citrate