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标题：Alteration of tumor markers may predict survival in colorectal cancer patients treated with TAS-102 or regorafenib as salvage-line chemotherapy: a single-institutional experience
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作者：Keiji Matsuda ; Keijiro Nozawa ; Kohei Ohno 等
期刊名称：Biomedical Research and Clinical Practice
电子版ISSN：2397-9631
出版年度：2017
卷号：2
期号：2
页码：1-5
DOI：10.15761-BRCP.1000136
语种：English
出版社：Open Access Text
摘要：Objectives: TAS-102 and regorafenib are novel antineoplastic drugs recommended for salvage-line chemotherapy. The objective of this study was to elucidate useful markers with predictive values for the effectiveness of these drugs. Methods: Between August 2013 and April 2016, 23 patients with refractory colorectal cancer received salvage-line chemotherapy at Teikyo University Hospital, Japan. 15 patients received TAS-102 monotherapy and 15 received regorafenib, including seven who had dual therapies. Tumor markers were analyzed for possible correlations with tumor response and the patients’ prognoses after these treatments. Results: Twelve patients of each group had radiologically measurable tumors. None of the TAS-102-treated patients achieved complete response (CR) or partial response (PR). After regorafenib therapy, no patients achieved CR, but one (8%) patient showed PR. These and the lack of correlation between the tumor responses and the patients’ overall survival (OS) suggested a limited predictive value of RECIST-based tumor evaluation in our study. Nonetheless, the OS of the patients with a decreased CA19-9 level after initial treatment with TAS-102 tended to be longer than that of the patients with an increased CA19-9 level (p=0.058). The OS of the patients with decreased CEA after initial regorafenib treatment was significantly longer than that of patients with increased CEA (p=0.03). Conclusions: The results of the present analysis suggest that CEA and CA19-9 may be more practical and useful as predictive/prognostic markers for refractory CRC patients treated with TAS-102 and regorafenib even when the predictive value of the tumor response measured using RECIST is not clear.
关键词：TAS-102; regorafenib; prognostic marker; CEA; CA19-9