文章基本信息

标题：Suppressive effect of mycolactone-containing fraction from Mycobacterium ulcerans <-em>on antibody production against co-administered antigens
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作者：Noriko Shinoda ; Hajime Nakamura ; Mineo Watanabe 等
期刊名称：Biomedical Research and Clinical Practice
电子版ISSN：2397-9631
出版年度：2017
卷号：2
期号：1
页码：1-6
DOI：10.15761-BRCP.1000126
语种：English
出版社：Open Access Text
摘要：Mycobacterium ulcerans infection causes Buruli ulcer, a chronic and destructive necrotizing skin ulcer in humans. The symptoms of Buruli ulcer are mainly caused by unique toxic macrolides, named mycolactone. The suppression of Th1-type immune responses and inflammatory responses is caused by mycolactone in humans and animal models. However, the effects of mycolactone on serum immune responses remain unclear. In this study, we administered model antigens with partially purified mycolactone into mice to examine its effect on antibody production in serum. Mycolactone-containing fraction suppressed antibody production against co-administered antigens in a dose-dependent manner. The suppressive effect was not observed when the antigens and mycolactone preparation were injected into different sites. Additionally, the effect was demonstrated only against co-administered antigens. Moreover, mycolactone-containing fraction was considered safe even at doses ten times higher than the dose that suppressed the antibody responses, suggesting potential usefulness of mycolactone as a new immunoregulatory agent to specifically prevent antibody response against co-administered antigens.