文章基本信息

标题：Enhanced Th17 responses with intestinal dysbiosis in human allergic, inflammatory, and autoimmune diseases
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作者：Jun Shimizu ; Noboru Suzuki
期刊名称：Biomedical Research and Clinical Practice
电子版ISSN：2397-9631
出版年度：2016
卷号：1
期号：3
页码：58-62
DOI：10.15761-BRCP.1000113
语种：English
出版社：Open Access Text
摘要：Researchers have shown that gut microbiota contributed to immune-system maturation and the microbiota compositional changes affected intestinal immune responses. The excessive immune reaction was suggested to spread over the entire blood vessels and induce distant organ damage. We have shown that T helper 17 (Th17) cells increased and had already been activated in vivo in patients with Behcet’s disease (BD). We hypothesized that intestinal dysbiosis (unfavorable changes of microbiota) continuously induced Th17 responses in patients with BD. A metagenomic analysis of patients with BD and normal individuals revealed that the family Lactobacillaceae, the genera Bifidobacterium and Eggerthella significantly increased in BD patients. The order Clostridiales and the genus Megamonas significantly increased in normal individuals. We suggest that lactate accumulation by increasing Lactobacillus and Bifidobacterium species and low short chain fatty acid concentrations induced by depletion of the order Clostridiales in the intestine may closely relate to the skewed T cell responses of patients with BD. In this review, we summarize recent advances in understanding of skewed T cell function and intestinal dysbiosis in human allergic, inflammatory, and autoimmune diseases.
关键词：intestinal dysbiosis; gut microbiota; metagenomics; Bifidobacterium; Th17 cells; IL23