文章基本信息

标题：Development of a cranium-infection rat model for artificial bone implantation
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作者：Yoshikazu Inoue ; Yoshiaki Sakamoto ; Hiroko Ochiai 等
期刊名称：Biomedical Research and Clinical Practice
电子版ISSN：2397-9631
出版年度：2016
卷号：1
期号：1
页码：18-21
DOI：10.15761-BRCP.1000105
语种：English
出版社：Open Access Text
摘要：For the development of infection-resistant artificial bone, a robust animal model that closely mimics clinical infection is necessary. Therefore, we established a rat model of cranial infection. After creating a bone defect in the parietal cranium of rats, either collagen sponge honeycomb or sterile cotton gauze was inserted into the defect, and wounds were then inoculated with Staphylococcus aureus. This method effectively resulted in cranial infection in a manner dependent on the inserted sponge/gauze.In conclusion, we believe this model will be useful as a cranial infection model and will enable studies of materials used in cranioplasty for their infection potential in a state befitting that of a clinical setting.
关键词：artificial bone; cranioplasty; cranial infection model; rat model