文章基本信息

标题：Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient
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作者：Eugenia Rota ; Paola Varese ; Luciano Arena 等
期刊名称：Clinical Management Issues
印刷版ISSN：2283-3137
出版年度：2021
卷号：15
期号：1
页码：1-5
DOI：10.7175/cmi.v15i1.1487
语种：English
出版社：SEEd
摘要：Literature on antiepileptic induced iatrogenic hypoglycemia is scanty. Due to its broad spectrum of activity and mechanisms of action, valproic acid (VPA), a fatty acid, is the most widely prescribed epilepsy treatment worldwide. Herein, we describe an adult epileptic patient, where persistent, otherwise unexplained hypoglycemia, was most likely induced by VPA, as suggested by the VPA time course and glucose blood levels. Indeed, no further hypoglycemic episodes occurred after VPA discontinuation and the diagnostic work-up ruled out other possible causes of hypoglycemia. This case supports the hypothesis that VPA may induce hypoglycemia, due to still not well-defined metabolic mechanisms of action. Moreover, it emphasizes the fact that an iatrogenic pathogenesis should be considered if an apparently unexplained hypoglycemia occurs in a patient on chronic therapy with antiepileptics, even at a therapeutical dosage.
关键词：hypoglycemia; valproic acid (VPA); epilepsy; side effects; diabetes mellitus; Jatrogenic effects; seizure