文章基本信息

标题：Allelic Frequency in Human SNPs Predicts the Rate of Non-Synonymous Nucleotide Substitutions between Human and Chimpanzee Genes
本地全文：下载
作者：Hippokratis Kiaris ; Athanasios G. Papavassiliou
期刊名称：Advances in Anthropology
印刷版ISSN：2163-9353
电子版ISSN：2163-9361
出版年度：2014
卷号：04
期号：01
页码：50-52
DOI：10.4236/aa.2014.41007
语种：English
出版社：Scientific Research Publishing
摘要：The combination of comparative genomics and population genetics may provide important clues regarding human evolution. We have hypothesized that the divergence between various human and chimpanzee orthologs will be reflected in the variability of single nucleotide polymorphisms (SNPs) that are localized in the vicinity of the corresponding loci in different human populations. Consistently with this notion, more diverged genes between humans and chimpanzees are more likely to be associated with human speciation and are anticipated to contain SNPs with reduced variability between different human populations. In order to test this hypothesis, we have compared the rate of non synonymous nucleotide substitutions (Ka) between 255 chimpanzee and human orthologs with the average deviation in the allelic frequencies of corresponding closely linked SNPs in two distinct human populations: The Yoruba people in Ibadan, Nigeria (YRI) and US residents with ancestry from Northern and Western Europe, collected in 1980 by the Centre d’Etude du Polymorphisme Humain (CEU). We found a significant (p
关键词：HapMap; Chimpanzee Genome; Human Speciation