文章基本信息

标题：Serum C-Reactive Protein Is Negatively Associated With Olfactory Identification Ability in Older Adults
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作者：Ingrid Ekström ; Davide Liborio Vetrano ; Goran Papenberg 等
期刊名称：i-Perception
电子版ISSN：2041-6695
出版年度：2021
卷号：12
期号：2
DOI：10.1177/20416695211009928
语种：English
出版社：Pion Ltd.
摘要：Importance Olfactory deficits are common in aging and associated with several conditions linked to inflammation. A few studies suggest that increased concentration of pro-inflammatory biomarkers may be related to olfactory deficits, but these associations are understudied in population-based samples. Objective To investigate the association between serum concentrations of C-reactive protein (CRP) and olfactory identification level as well as rate of change in aging. Methods We included 1,721 participants (mean age 70.5 years; 61.9% female) with at least two olfactory assessments across the 12-year follow-up. Baseline level and change in odor identification were estimated with linear mixed models as a function of CRP levels, derived from blood plasma at baseline. Results Results indicated a negative dose–response association between CRP level and odor identification scores at baseline, after adjustment for demographic, cognitive, health, and lifestyle factors. CRP levels ranging between 11 and 20 mg/L were significantly related to lower olfactory ability (β = −0.811, 95% confidence interval [CI
关键词：inflammation; olfaction; odor; aging; CRP; sex differences