文章基本信息

标题：A unified resource and configurable model of the synapse proteome and its role in disease
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作者：Oksana Sorokina ; Colin Mclean ; Mike D. R. Croning 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-88945-7
语种：English
出版社：Springer Nature
摘要：Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein–protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.