文章基本信息

标题：Modeled Respiratory Tract Deposition of SmokeAerosol from Conventional Cigarettes, ElectronicCigarettes and Heat-not-burn Products
本地全文：下载
作者：Yawen Li ; Huapeng Cui ; Li Chen 等
期刊名称：Aerosol and Air Quality Research
印刷版ISSN：1680-8584
出版年度：2021
卷号：21
期号：5
页码：1-16
DOI：10.4209/aaqr.200241
语种：English
出版社：Chinese Association for Aerosol Research in Taiwan
摘要：Knowledge of the deposition of inhaled smoke aerosol in the human respiratory tract has greatvalue for risk assessments of the inhalation toxicology of tobacco products. In this study,differential mobility spectrometry (DMS) was used to characterize smoke particles generatedfrom a conventional cigarette, e-cigarette and heat-not-burn product. The aerosol propertiesobtained by DMS were then applied to a Multiple Path Particle Dosimetry (MPPD) model topredict the deposition of aerosol particles in the human respiratory tract. The DMS resultsshowed that the particle size distribution of aerosol from the three products differed considerably,with a count median diameter of 14.2–25.4 nm, 50.6–55.3 nm and 172–179 nm for the e-cigarette,heat-not-burn product and conventional cigarette, respectively. However, there was no significantdifference in the particle number concentration of aerosol from the three products. The MPPDmodel indicated that the total deposition fraction of aerosol particles from the e-cigarette andheat-not-burn product was higher than that from the conventional cigarette, and deposition ofparticles from the e-cigarette in the three human airway regions (head airway, tracheobronchialand pulmonary regions) was higher than that from the heat-not-burn product and conventionalcigarette; the particle number concentration deposited in the pulmonary region was the highest,comprising more than 60% of total deposition. Lastly, among the lung lobes, the highest numberdeposition fraction occurred in the right lower lobe. The relationship between deposition fractionand airway generation was relatively similar among the three aerosols, and the highestdeposition fraction occurred in the 20th to 23rd generation airways. The deposition results showedthat smaller particles, such as those from the e-cigarette aerosol, were more easily deposited inthe human respiratory tract. Combined with knowledge of the harmful aerosol constituents,these deposition data will provide important information for hazard evaluation of new tobaccoproducts.
关键词：Conventional cigarette;E-cigarette;Heat-not-burn product;Aerosol property;Respiratory tract;MPPD-modeled deposition