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标题：Role of NKG2a/c +CD8 + T cells in pathogenic versus non-pathogenic SIV infections
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作者：Nicolas Huot ; Philippe Rascle ; Nicolas Tchitchek 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：4
页码：1-37
DOI：10.1016/j.isci.2021.102314
语种：English
出版社：Elsevier
摘要：SummarySome viruses have established an equilibrium with their host. African green monkeys (AGM) display persistent high viral replication in the blood and intestine during Simian immunodeficiency virus (SIV) infection but resolve systemic inflammation after acute infection and lack intestinal immune or tissue damage during chronic infection. We show that NKG2a/c+CD8+T cells increase in the blood and intestine of AGM in response to SIVagm infection in contrast to SIVmac infection in macaques, the latter modeling HIV infection. NKG2a/c+CD8+T cells were not expanded in lymph nodes, and CXCR5+NKG2a/c+CD8+T cell frequencies further decreased after SIV infection. Genome-wide transcriptome analysis of NKG2a/c+CD8+T cells from AGM revealed the expression of NK cell receptors, and of molecules with cytotoxic effector, gut homing, and immunoregulatory and gut barrier function, including CD73. NKG2a/c+CD8+T cells correlated negatively with IL-23 in the intestine during SIVmac infection. The data suggest a potential regulatory role of NKG2a/c+CD8+T cells in intestinal inflammation during SIV/HIV infections.Graphical abstractDisplay OmittedHighlights•Molecular determination of NKG2a/c+CD8+T cells in two species of nonhuman primates•Tissue distribution of NKG2a/c+CD8+T cell is profoundly sculpted by SIV infections•Intestinal NKG2a/c+CD8+T cells correlated negatively with IL-23 in SIV infection•NKG2a/c+CD8+T cells might play a protective gut barrier function in HIV/SIV infectionImmunology ; Viral Microbiology ; Transcriptomics