文章基本信息

标题：Nutrient infusion in the dorsal vagal complex controls hepatic lipid and glucose metabolism in rats
本地全文：下载
作者：Rosa J.W. Li ; Battsetseg Batchuluun ; Song-Yang Zhang 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：4
页码：1-25
DOI：10.1016/j.isci.2021.102366
语种：English
出版社：Elsevier
摘要：SummaryHypothalamic regulation of lipid and glucose homeostasis is emerging, but whether the dorsal vagal complex (DVC) senses nutrients and regulates hepatic nutrient metabolism remains unclear. Here, we found in rats DVC oleic acid infusion suppressed hepatic secretion of triglyceride-rich very-low-density lipoprotein (VLDL-TG), which was disrupted by inhibiting DVC long-chain fatty acyl-CoA synthetase that in parallel disturbed lipid homeostasis during intravenous lipid infusion. DVC glucose infusion elevated local glucose levels similarly as intravenous glucose infusion and suppressed hepatic glucose production. This was independent of lactate metabolism as inhibiting lactate dehydrogenase failed to disrupt glucose sensing and neither could DVC lactate infusion recapitulate glucose effect. DVC oleic acid and glucose infusion failed to lower VLDL-TG secretion and glucose production in high-fat fed rats, while inhibiting DVC farnesoid X receptor enhanced oleic acid but not glucose sensing. Thus, an impairment of DVC nutrient sensing may lead to the disruption of lipid and glucose homeostasis in metabolic syndrome.Graphical abstractDisplay OmittedHighlights•DVC oleic acid infusion lowers hepatic secretion of VLDL-TG in chow but not HF rats•Inhibition of ACSL in the DVC negates lipid sensing•DVC glucose infusion lowers hepatic glucose production in chow but not HF rats•Inhibition of FXR in the DVC enhances oleic acid but not glucose sensing in HF ratsBiological Sciences; Physiology; Endocrinology