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标题：Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers
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作者：Osbaldo Lopez-Charcas ; Piyasuda Pukkanasut ; Sadanandan E. Velu 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：4
页码：1-26
DOI：10.1016/j.isci.2021.102270
语种：English
出版社：Elsevier
摘要：SummaryVoltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervix, whereas they are not expressed in cognate non-cancer tissues. Their activity was demonstrated to promote aggressive and invasive potencies of cancer cells, bothin vitroandin vivo, whereas their deregulated expression in cancer tissues has been associated with metastatic progression and cancer-related death. This review proposes NaVchannels as pharmacological targets for anticancer treatments providing opportunities for repurposing existing NaV-inhibitors or developing new pharmacological and nutritional interventions.Graphical abstractDisplay OmittedCell Biology; Cancer