文章基本信息

标题：ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
本地全文：下载
作者：Xiaoyuan Lin ; Beibei Fu ; Songna Yin 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：4
页码：1-24
DOI：10.1016/j.isci.2021.102293
语种：English
出版社：Elsevier
摘要：SummaryRecently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a potential target for the development of COVID-19 therapeutic drugs.Graphical abstractDisplay OmittedHighlights•SARS-CoV-2 ORF8 activates IL-17 signaling pathway by interacting with host IL17RA•Treatment of IL17RA antibody protects mice from ORF8-induced inflammationBiological Sciences; Microbiology; Virology