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标题：Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men
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作者：Mounir Ould Setti ; Ari Voutilainen ; Tomi-Pekka Tuomainen 等
期刊名称：Epidemiology and Health
印刷版ISSN：2092-7193
出版年度：2021
卷号：43
DOI：10.4178/epih.e2021001
语种：English
出版社：Taehan P'ibu Kwahakhoe
摘要：Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver. METHODS Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up for a median of 29 years. Associations among RHF, fatty liver index (FLI) score, age, body mass index, smoking status, alcohol consumption, and hypertension status were assessed using logistic regression. Cox proportional hazards models were used to determine the hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality with respect to RHF and fatty liver. RESULTS Of the men, 5% had RHF (n=73), whereas a majority had fatty liver (n=848). RHF was associated specifically with smoking, and fatty liver was associated specifically with overweight. The all-cause mortality hazard was highest (HR, 1.96; 95% confidence interval [CI
关键词：Mortality; Cardiovascular diseases; Heart disease risk factors; Glomerular filtration rate; Fatty liver; Non-alcoholic fatty liver disease