文章基本信息

标题：Antithetic integral feedback for the robust control of monostable and oscillatory biomolecular circuits
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作者：Noah Olsman ; Fulvio Forni
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2020
卷号：53
期号：2
页码：16826-16833
DOI：10.1016/j.ifacol.2020.12.1176
语种：English
出版社：Elsevier
摘要：AbstractBiomolecular feedback systems are now a central application area of interest within control theory. While classical control techniques provide valuable insight into the function and design of both natural and synthetic biomolecular systems, there are certain aspects of biological control that have proven difficult to analyze with traditional methods. To this end, we describe here how the recently developed tools of dominance analysis can be used to gain insight into the nonlinear behavior of the antithetic integral feedback circuit, a recently discovered control architecture which implements integral control of arbitrary biomolecular processes using a simple feedback mechanism. We show that dominance theory can predict both monostability and periodic oscillations in the circuit, depending on the corresponding parameters and architecture. We then use the theory to characterize the robustness of the asymptotic behavior of this circuit in a nonlinear setting.
关键词：KeywordsSynthetic BiologyAntithetic Integral FeedbackNonlinear ControlDominance Theory