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标题：Effects of sugar and honey on the formation of collagen fibers in incision wound of domestic cat ( Felis domestica)
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作者：R Ummah ; W S Monica ; D K Sari 等
期刊名称：IOP Conference Series: Earth and Environmental Science
印刷版ISSN：1755-1307
电子版ISSN：1755-1315
出版年度：2020
卷号：575
期号：1
DOI：10.1088/1755-1315/575/1/012025
语种：English
出版社：IOP Publishing
摘要：This study aimed to determine the effect and comparison of histopathological features of the skin of domestic cat (Felis domestica) on the formation of collagen fibers in the incise wound after treated by sugar and honey. Materials and methods in this study 15 male domestic cats were used in this study and were divided into five groups of Negative control group (KKN) without treatment, Positive control group (KKP) used Bioplacenton®, Group 1 (KP1) used sugar, Group 2 (KP2) used honey and Group 3 (KP3) used sugar and honey (combination) for 14 days, topically. The incision wound was made on the back of the domestic cat and the treatments were given daily for 14 days; the skin samples were taken on days 4, 9 and 14 to observe the formation of collagen fibers. The process of collagen fibers formation was observed and scoring was done from score 0 to +4 based on the density of collagen fibers in the wound area. Score changes data were analyzed descriptively. Results showed that KKN and KP2 collagen fibrous density was similar at day 4 score 0, day 9 score +1, and day 14 score +2. KP1 and KP3 collagen fibrous density were similar at day 4 score +1, day 9 score +2, and day 14 score +3. While KKP collagen fibrous density was high at day 4 score+1, day 9 score +3, and day 14 score +4. KP3 showed a good collagen fiber formation with the density was almost similar to the positive control group (KKP). The control groups (KKN and KKP) and the treatment groups (KP1, KP2 and KP3) showed differences in the formation of collagen fibers, fibroblast cells and the discovery of inflammatory cells on days 4, 9 and 14 during the wound healing process. The provision of sugar and honey in combination showed a good influence in the process of formation of collagen fibers during the wound healing process.