文章基本信息

标题：How well do brain organoids capture your brain?
本地全文：下载
作者：Jonghun Kim ; Gareth J. Sullivan ; In-Hyun Park 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：2
页码：1-14
DOI：10.1016/j.isci.2021.102063
语种：English
出版社：Elsevier
摘要：SummaryBrain organoids closely recapitulate many features and characteristics ofin vivobrain tissue. This technology in turn allows unprecedented possibilities to investigate brain development and function in the dish. Several brain organoid protocols have been established, and the studies have focused on validating the architecture, cellular composition, and function of the organoids. In future, the improved and advanced organoid models will enable us to understand cellular and molecular features of the developing brain. However, several obstacles, such as the quality of the organoids, 3D structural analysis, and measurement of the neural connectivity need to be improved. In this perspective, we will provide an overview of the current state of the art of the brain organoid field, with a focus on protocols and organoid characterization. Additionally, we will address the current limitations of this evolving field and provide an understanding of the current brain organoid landscape and insight toward the next steps.Graphical abstractDisplay OmittedNeuroscience; tissue engineering