文章基本信息

标题：The IL-27 receptor regulates TIGIT on memory CD4 + T cells during sepsis
本地全文：下载
作者：Kristen N. Morrow ; Zhe Liang ; Ming Xue 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：2
页码：1-26
DOI：10.1016/j.isci.2021.102093
语种：English
出版社：Elsevier
摘要：SummarySepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we found that IL-27Rα was associated with the upregulation of TIGIT on memory CD4+T cells following CLP. However, IL-27 was not associated with sepsis mortality.Graphical AbstractDisplay OmittedHighlights•Numbers of IL-27Rα+memory T cells are decreased following cecal ligation and puncture•TIGIT is expressed on more IL-27Rα+versus IL-27Rα−memory CD4+T cells during sepsis•Il27ra−/−and WT T cells exhibit similar effector function and apoptosis during sepsis•IL-27 signaling does not impact sepsis mortalityMolecular Biology; Immunology