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标题：Antimicrobial resistance patterns and their encoding genes among clinical isolates of Acinetobacter baumannii in Ahvaz, Southwest Iran
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作者：Mojtaba Moosavian ; Khadijeh Ahmadi ; Saeed Shoja 等
期刊名称：MethodsX
印刷版ISSN：2215-0161
电子版ISSN：2215-0161
出版年度：2020
卷号：7
页码：1-8
DOI：10.1016/j.mex.2020.101031
语种：English
出版社：Elsevier
摘要：AbstractAcinetobacter baumanniiis one of the most important organisms in nosocomial infections. Antibiotic resistance in this bacterium causes many problems in treating patients. This study aimed to investigate antibiotic resistance patterns and resistance-related,genes in clinical isolates ofAcinetobacter baumannii.This descriptive study was conducted on 124 isolates ofAcinetobacter baumanniicollected from clinical samples in two teaching hospitals in Ahvaz. The antibiotic resistance pattern was determined by disk diffusion. The presence of genes coding for antibiotic resistance was determined using the polymerase chain reaction method. Out of 124 isolates, the highest rate of resistance was observed for rifampin (96.8%). The resistance rate for imipenem, meropenem, colistin, and polymyxin-B were 78.2%, 73.4%, 0.8% and 0.8%, respectively. The distribution ofqnrA, qnrB, qnrS, Tet A, TetB,andSul1genes were 52.6%, 0%, 3.2%, 93.5% 69.2%, and 6.42%, respectively. High prevalence oftetA, tetB,andqnrAgenes amongAcinetobacter baumanniiisolated strains in this study indicate the important role of these genes in multidrug resistance in this bacteria.•Acinetobacter baumanniiis an important human pathogen that has attracted the attention of many researchers Antibiotic resistance in this bacterium causes many problems in treating patients.• The resistance rate for imipenem, meropenem, colistin, and polymyxin-B were 78.2%, 73.4%, 0.8% and 0.8%, respectively. The distribution ofqnrA, qnrB, qnrS, Tet A, TetB,andSul1genes were 52.6%, 0%, 3.2%, 93.5% 69.2%, and 6.42%, respectively.Graphical abstractDisplay Omitted
关键词：Acinetobacter baumannii;qnr;Antibiotic resistance;PCR