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标题：Selenium nanoparticles mitigate diabetic nephropathy and pancreatopathy in rat offspring via inhibition of oxidative stress
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作者：Iftekhar Hassan ; Hossam Ebaid ; Jameel Al-Tamimi 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2021
卷号：33
期号：1
页码：1-7
DOI：10.1016/j.jksus.2020.101265
语种：English
出版社：Elsevier
摘要：AbstractGestational diabetes (G.D.) and its effects on the offspring are some of the major concerns in the mothers of the 21st century. The present study investigates if selenium nanoparticles (SeNPs) can prevent G.D.'s ill effect in the pups to the diabetic mother rats. For this study, the rats were distributed in three groups as per treatment given to their diabetic mothers: DM (p) [diabetic pups from diabetic mothers]; D.M. + Se-NP (pups from diabetic mothers treated with Se N.P. at the dose of 5 mg/kg body weight twice a week for a month) beside the control group (C.N.). The pups were sacrificed, and their blood, pancreas, and kidney were preserved for their biochemical analysis and histological evaluation. The biochemical study, including renal markers (urea, creatinine, and albumin in serum samples), showed a prominent positive effect of the N.P.s in the pups compared to the D.M. group. The redox parameters (reduced glutathione and malondialdehyde levels in tissue samples) were correctly modulated in the pups from N.P.s treated diabetic mothers. These findings were in agreement with the histological examination of the kidney and pancreas tissue samples. The N.P.s showed restoration of various histological details in the pups from the NPs-treated mothers. The current findings entail that the N.P.s counter the possible diabetic-related complications in the offspring by reorganizing the cellular redox status. Hence, the present study shows that SeNPs contain G.D. in diabetic mothers and don't allow the passage to their offspring.
关键词：Selenium;Nanoparticles;Diabetes;Nephropathy;Pancreatopathy;Offspring;Oxidative stress