文章基本信息

标题：Congenital Hypothyroidism and its Related Factors in an Iranian Population: A Retrospective Study in Semnan (2011–2016)
本地全文：下载
作者：Soraya Doustmohamadian ; Sahar Mehrizi ; Mohammad Naser Rahbar 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2020
卷号：11
DOI：10.4103/ijpvm.IJPVM_254_19
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: Congenital hypothyroidism (CH) is an important and preventable cause of intellectual disability. This study determined the incidence of CH and its related factors in Semnan city in Iran. Methods: All neonates born in Semnan from 2011 to 2016 who participated in a screening program for CH were evaluated to estimate the incidence of CH. In a nested case-control study, all diagnosed CH cases were compared with a control group of healthy newborns. Statistical analysis used conditional logistic regression model with STATA-14. Results: 106 out of 17,507 neonates born in Semnan during 2011–2016 were diagnosed with CH (6.05 cases per 1,000 live births). Maternal parity (odds ratio [OR] =1.78, P = 0.044), birth weight (OR = 0.29, P = 0.001), parental history of thyroid disease (OR = 3.43, P = 0.001), father's education (OR = 0.71, P = 0.003), father's occupation (nonworker) (OR = 2.97, P = 0.001), and the presence of other anomalies (OR = 4.14, P = 0.037) were related to the incidence of CH. Conclusions: The cumulative incidence of CH in Semnan was higher than in both the global and national statistics. Aside from well-known medical determinants, some important social factors such as father's occupation and education have a significant and independent relationship with occurrence of CH; rational attention should be given to them in health care programs to increase the effectiveness of preventative measures for CH.