文章基本信息

标题：Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery
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作者：Hoda Safari Yazd ; Yu Yang ; Long Li 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：12
页码：1-29
DOI：10.1016/j.isci.2020.101750
语种：English
出版社：Elsevier
摘要：SummaryCompared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted release of anticancer drugs, and achieve targeted killing of tumor cells. However, many natural receptors are also expressed on non-cancer cells, thereby diverting the targeting molecules to healthy cells. By generating artificial cell surface receptors specific to diseased cells, aptamer-drug conjugates can identify these artificial receptors, improve therapeutic efficacy, and decrease the minimum effective dosage. In this study, we use high K+and high H2O2of the tumor microenvironment (TME) to produce polydopamine only on living cancer cell membrane. Owing to the significant reactivity of polydopamine with amino groups, e.g., the amino group of proteins, polydopamine can deposit on tumor cells and act as “artificial receptors” for targeted delivery of anticancer drugs with amino groups, in other words, amino-containing drugs and protein drugs.Graphical AbstractDisplay OmittedHighlights•Polydopamine (PDA) generation catalyzed using G-quadruplex DNAzyme•TME high K+and H2O2employed to produce PDA only on cancerous cells membrane•PDA generated and deposited on cancerous cells and acted as artificial receptors•PDA artificial receptors facilitated targeted delivery of drugs with amino groupsDrug Delivery System; Cancer; Biomaterials