文章基本信息

标题：Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice
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作者：Amber M. Paul ; Margareth Cheng-Campbell ; Elizabeth A. Blaber 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：12
页码：1-30
DOI：10.1016/j.isci.2020.101747
语种：English
出版社：Elsevier
摘要：SummarySpaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, compared with data from astronauts on International Space Station missions. For ground studies, we simulated microgravity using the hindlimb unloaded mouse model alone or in combination with acute simulated galactic cosmic rays or solar particle events irradiation. Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight. Circulating plasma microRNA sequence analysis revealed involvement in immune system dysregulation. Furthermore, a large astronaut cohort showed elevated inflammation during low-Earth orbit missions, thereby supporting our simulated ground experiments in mice. Herein, circulating immune biomarkers are defined by distinct deep space irradiation types coupled to simulated microgravity and could be targets for future space health initiatives.Graphical AbstractDisplay OmittedHighlights•Murine immune profiles from simulated deep spaceflight conditions were analyzed•Immune profiling revealed unique immune diversity with each experimental condition•Plasma microRNA sequence analysis revealed involvement in immune system dysregulation•Astronaut data showed elevated inflammation during low-Earth orbit missionsImmunology; Space Sciences