文章基本信息

标题：GABA Modulates Frequency-Dependent Plasticity in Humans
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作者：Caroline A. Lea-Carnall ; Stephen R. Williams ; Faezeh Sanaei-Nezhad 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：11
页码：1-18
DOI：10.1016/j.isci.2020.101657
语种：English
出版社：Elsevier
摘要：SummaryFrequency-dependent reorganization of the primary somatosensory cortex, together with perceptual changes, arises following repetitive sensory stimulation. Here, we investigate the role of GABA in this process. We co-stimulated two finger tips and measured GABA and Glx using magnetic resonance (MR) spectroscopy at the beginning and end of the stimulation. Participants performed a perceptual learning task before and after stimulation. There were 2 sessions with stimulation frequency either at or above the resonance frequency of the primary somatosensory cortex (23 and 39 Hz, respectively). Perceptual learning occurred following above resonance stimulation only, while GABA reduced during this condition. Lower levels of early GABA were associated with greater perceptual learning. One possible mechanism underlying this finding is that cortical disinhibition “unmasks” lateral connections within the cortex to permit adaptation to the sensory environment. These results provide evidence in humans for a frequency-dependent inhibitory mechanism underlying learning and suggest a mechanism-based approach for optimizing neurostimulation frequency.Graphical AbstractDisplay OmittedHighlights•In the context of repetitive sensory stimulation, GABA release is frequency dependent•Stimulating above the resonance frequency of the somatosensory cortex reduces GABA•Perceptual learning is associated with a reduction in GABA•Early GABA reduction opens a window for plasticity and learningMolecular Neuroscience; Systems Neuroscience; Cognitive Neuroscience