文章基本信息

标题：Ecological and Evolutionary Consequences of Anticancer Adaptations
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作者：Justine Boutry ; Antoine M. Dujon ; Anne-Lise Gerard 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：11
页码：1-13
DOI：10.1016/j.isci.2020.101716
语种：English
出版社：Elsevier
摘要：SummaryCellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.Graphical AbstractDisplay OmittedBiological Sciences; Evolutionary Biology; Evolutionary Ecology; Cancer Systems Biology