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标题：Screening of anti-oxidant and anti-bacterial metabolites from brown algae Turbinaria ornata for inhibits the multi-drug resistant P. aeruginosa
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作者：Naiyf S. Alharbi ; Sami A. Alyahya ; Govindan Ramachandran 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：8
页码：3447-3453
DOI：10.1016/j.jksus.2020.10.005
语种：English
出版社：Elsevier
摘要：AbstractIn this study, the anti-oxidant and anti-bacterial activity of marine brown algaeTurbinaria ornata(T. ornate) extract was purified by soxhlet apparatus method. Theinvitrostudies of total anti-oxidant activity and DPPH hydroxyl scavenging activity assays were suggested that theT. ornataextract has more anti-oxidant activity. Agar well diffusion and minimum inhibition concentration results were exhibited excellent inhibition effect ofT. ornataextract againstP. aeruginosaat 300 µg/mL concentration. The time-dependent bacterial inhibition assay was also confirmed the 300 µg/mL concentration at 24 h. Further, the increased death cells and extracellular shape alteration results were observed by confocal laser scanning electron microscope and scanning electron microscope. Therefore, our result was suggested that theT. ornataextract as a promising anti-bacterial agent for multi-drug resistantP. aeruginosa.
关键词：Marine environment;Brown algae;Anti-oxidant;Minimum inhibition concentration;Intracellular death;Morphological damage