文章基本信息

标题：Investigation of the Zinc Oxide Nanoparticles Effect on Testosterone, Cholesterol and Cortisol in Rats
本地全文：下载
作者：Reza EspananiHamid ; Kobra Shirani ; Saadat Khalilian 等
期刊名称：Research Journal of Recent Sciences
电子版ISSN：2277-2502
出版年度：2014
卷号：3
期号：4
页码：14-19
语种：English
出版社：International Science Community Association
摘要：Nowadays nanoparticles have widespread application in various industries because of their special and unique features. There are many studies in side effects of nanomaterial but these studies used from high doses and specially ZnOnanoparticles in low dose was less researched. This study done by 36 Wistar rats with every other day injection of different doses of ZnOnanoparticles intraperitoneally (5, 10, 20 and 40 mg / kg). After a 21-day period, the rats were bled and whole blood hematocrit and lymphocyte numbers and serum levels of cholesterol, cortisol and testosterone hormone were measured. The results showed a significant decrease of cortisol level and significant increase of testosterone and cholesterol level of blood serum in rats that injected by ZnOnanoparticles rather than controls. Number of lymphocyte in treated rats reduced and hematocrit showed an irregular variation. Therefore all of results confirmed exposing to ZnOnanoparticles damaged to public health and reduced fertility potential.
关键词：Cholesterol;cortisol;nano zinc oxide;testosterone;Wistar rats