文章基本信息

标题：FGF13 Is a Novel Regulator of NF-κB and Potentiates Pathological Cardiac Hypertrophy
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作者：Jia Sun ; Chao Niu ; Weijian Ye 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：10
页码：1-45
DOI：10.1016/j.isci.2020.101627
语种：English
出版社：Elsevier
摘要：SummaryFGF13 is an intracellular FGF factor. Its role in cardiomyopathies has been rarely investigated. We revealed that endogenous FGF13 is up-regulated in cardiac hypertrophy accompanied by increased nuclear localization. The upregulation of FGF13 plays a deteriorating role both in hypertrophic cardiomyocytes and mouse hearts. Mechanistically, FGF13 directly interacts with p65 by its nuclear localization sequence and co-localizes with p65 in the nucleus in cardiac hypertrophy. FGF13 deficiency inhibits NF-κB activation in ISO-treated NRCMs and TAC-surgery mouse hearts, whereas FGF13 overexpression shows the opposite trend. Moreover, FGF13 overexpression alone is sufficient to activate NF-κB in cardiomyocytes. The interaction between FGF13 and p65 or the effects of FGF13 on NF-κB have nothing to do with IκB. Together, an IκB-independent mechanism for NF-κB regulation has been revealed in cardiomyocytes both under basal and stressful conditions, suggesting the promising application of FGF13 as a therapeutic target for pathological cardiac hypertrophy and heart failure.Graphical AbstractDisplay OmittedHighlights•Endogenous FGF13 is up-regulated in cardiomyocytes under pressure overload•FGF13 directly interacts with p65•Forced FGF13 overexpression activates NF-κB in cardiomyocytesPathophysiology; Cell Biology