文章基本信息

标题：Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis
本地全文：下载
作者：Satoshi Hirose ; Pedram Shafiei Jahani ; Shaohui Wang 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：10
页码：1-22
DOI：10.1016/j.isci.2020.101549
语种：English
出版社：Elsevier
摘要：SummaryWe previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination. Histologic examination of infected IL-2rα−/−, IL-2rβ−/−, and IL-2rγ−/−mice showed demyelination in the CNS of IL-2rα−/−and IL-2rβ−/−mice but not in the CNS of IL-2rγ−/−-infected mice. No demyelination was detected in mice infected with control virus. IL-2rγ−/−mice that lack type 2 innate lymphoid cells (ILC2s) and ILCs, play important roles in host defense and inflammation. We next infected ILC1−/−, ILC2−/−, and ILC3−/−mice with HSV-IL-2 or wild-type (WT) HSV-1. In contrast to ILC1−/−and ILC3−/−mice, no demyelination was detected in the CNS of ILC2−/−-sinfected mice. However, transfer of ILC2s from WT mice to ILC2−/−mice restored demyelination in infected recipient mice. CNS demyelination correlated with downregulation of CCL5 and CXCL10. This study demonstrates that ILC2s contribute to HSV-IL-2-induced CNS demyelination in a mouse model of multiple sclerosis.Graphical AbstractDisplay OmittedHighlights•IL-2rγ−/−, but not IL-2rα−/−or IL-2rβ−/−, mice are protected from CNS demyelination•Mice lacking ILC2s, but not ILC1s or ILC3s, are protected from CNS demyelination•Transfer of ILC2s from WT to ILC2−/−mice restore CNS demyelination to infected mice•Suppression of CCL5 and CXCL10 correlated with CNS demyelinationImmunology; Neuroscience