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标题：Anticancer and antioxidant efficacy of silver nanoparticles synthesized from fruit of Morinda citrifolia Linn on Ehrlich ascites carcinoma mice
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作者：Karuppaiah Jeyaprakash ; Mohamad S. AlSalhi ; Sandhanasamy Devanesan 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：7
页码：3181-3186
DOI：10.1016/j.jksus.2020.09.005
语种：English
出版社：Elsevier
摘要：AbstractThe M. citrifolia, commonly called starvation fruit, plays an essential role in daily dietary intakes, as it contains several vitamins, phytochemicals, and electrolytes. These constituents have several biological activities that are anti-tumor, antibacterial, antiviral, antifungal, and play a role in the immune system. The silver nanoparticles (AgNPs) were synthesized using a more uncomplicated and fast means using theM. citrifoliafruit samples. The Silver ions (Ag+) readily get reduced to (Ag0) to performM. CitrifoliaAgNPs hence the fruit extracts ofM. Citrifoliacan be considered potential lowering agents. The preliminary confirmation was done qualitatively by change of color into brownish-black, and the color change was observed due to bio-reduction and the Surface Plasmon Resonance (SPR) vibration. It was established by the absorbance peak at 430 nm using UV–Visible spectral analysis. Scanning Electron microscopy (SEM) showed the particle size ranging from 12 to 26 nm. Fourier-transform infrared spectroscopy (FTIR) confirmed the presence of the functional groups from synthesizedM. citrifoliaAgNPs.The biochemical studies were supported by the effect of antioxidant and anticancer properties ofM. citrifoliaAgNPs. The pathological changes were studied using hematoxylin, and Eosin staining in Albino mice, which was no tumor (Ehrlich ascites carcinoma) cell invasion exhibited in Fluorouracil treated group. The present investigation proves that theM. citrifoliafruit extract derived AgNPs is a promising antioxidant agent to treat liver cancer.
关键词：Ehrlich carcinoma;AgNPs;Morinda citrifolia;Liver cancer;Antioxidant