文章基本信息

标题：A simple, rapid, expedient and sustainable green strategy for the synthesis of benz-/naphthimidazoles
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作者：Abdulrahman I. Almansour ; Raju Suresh Kumar ; Natarajan Arumugam 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：7
页码：3153-3158
DOI：10.1016/j.jksus.2020.09.001
语种：English
出版社：Elsevier
摘要：Graphical abstractDisplay OmittedAbstractA versatile green chemical procedure for the highly selective construction of 2-aryl substituted benz-/naphthimidazoles starting from the reaction of aromatic 1,2-diamines with a series of substituted arylthioprolines with three to five drops of water under simple grinding at ambient temperature in good yields is described. The short reaction time, simplified experimental procedure, the absence of extraction and chromatographic purification steps in addition to the environment affability makes this green strategy highly attractive in view of green chemistry. The expected reaction to furnish the thiazole grafted benz-/naphthimidazole did not occur. Perhaps the arylthioprolines could be in zwitterionic form, which could react with 1,2-diamine giving dihyrobenzimidazole, which undergoes air oxidation to furnish the 2-aryl benzimidazole rather than the expected thiazole grafted imidazoles.
关键词：Green chemistry;Arylthioprolines;Benzimidazole;Naphthimidazole;Selectivity