文章基本信息

标题：An efficient, sustainable approach to the chemo and regioselective synthesis of novel spiroindenoquinoxaline grafted piperidone hybrid heterocycles
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作者：Abdulrahman I. Almansour ; Natarajan Arumugam ; Raju Suresh Kumar 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：7
页码：3059-3064
DOI：10.1016/j.jksus.2020.08.013
语种：English
出版社：Elsevier
摘要：AbstractAn efficient, eco-friendly and sustainable approach for the synthesis of novel spiroindeno[1,2-b]quinoxaline-3-phenylspiro[4,3″]benzylidenepiperidone ring system has been developed by a one-pot four component [3 + 2] cycloaddition strategy. The 1,3-dipole generatedin situfrom quinoxalinone andl-phenylalanine reacts with the highly functionalized dipolarophiles, bisarylidene piperidones affording spirohybrid heterocycles in good yields. The unexplored novel class of dispirohybrid heterocycles obtained possess three CN and two CC bonds with four adjacent stereogenic carbons, out of which two is spirocarbons. The structure of compounds was elucidated using1H,13C and mass spectroscopic studies.
关键词：Azomethine ylide;Spiroindenoquinoxalinone;Spiropyrrolidines;Benzylidene piperidone;Ionic liquids