文章基本信息

标题：Hyper-ovulation, endometriosis, and hyperplasia associated with tamoxifen exposure in Swiss albino mice
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作者：Iman Ali Al-Anazy ; Badr Al-Dahmash ; Doaa Mohamed El-Nagar 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：7
页码：3026-3031
DOI：10.1016/j.jksus.2020.08.008
语种：English
出版社：Elsevier
摘要：The available literature on the safety profile of tamoxifen in human patients and in experimental animals is mostly contradictory. The present study was therefore, designed to understand the safety profile of tamoxifen using Swiss albino mice. Swiss albino mice of age 13 weeks were orally administered tamoxifen (35 mg/kg/day) for 80 days. The breast, liver, and ovaries were used to evaluate the toxicity of tamoxifen in these organs using histopathology by H& E staining, the organ indices, estimation of liver enzymes, sex hormones, and antioxidant enzymes were compared with control mice group. The histopathological profiles indicated that breasts of the treated mice were not affected; however, it caused major damage to the liver, uterus, and ovaries. Tamoxifen also induced a moderate level of apoptosis by elevating the level of caspase-3 in the liver, uterus, and ovaries of the treated mice. The estrogen and progesterone levels were also significantly reduced. Tamoxifen induced hyper ovulation in treated mice group which has never been reported before. These data suggest that hepatotoxicity and hyper ovulation associated with tamoxifen could not be overruled and hence an alternate hormone disruptors other than tamoxifen should be investigated.
关键词：Tamoxifen;Hormone disruptors;Liver enzymes;Caspase-3