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标题：Correlational analyses between the production of anti-nuclear antibodies and biomarkers of acute aortic syndrome
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作者：Jian Shi ; Yaping Guo ; Jingyun Yang 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：7
页码：2920-2923
DOI：10.1016/j.jksus.2020.04.013
语种：English
出版社：Elsevier
摘要：AbstractObjectiveMarkers of serological autoimmunity such as anti-nuclear antibodies (ANA) are noted in approximately 14.01% of the Chinese population. The vast majority will do not have clinical autoimmune disease. However, the possible influence of antinuclear antibodies in acute aortic syndromes (AAS) has not been elucidated.MethodsThe study group included 77 patients who underwent AAS. Serum levels of antinuclear (ANA) were tested. Patients detailed data on AAS risk factors and markers of subclinical index (including C-reactive protein, D-dimmer, Glucose, Creatine kinase) were available. Results: Of the 77 patients with AAS, 40 had classic acute aortic dissection 29 variants intramural hematoma (IMH) and 8 penetrating atherosclerotic ulcer (PAU). Among the control group, 12/76 (15.8%) were ANA positive. In marked contrast, among the study subjects 30/77 (39.0%) were ANA positive. There is a higher incidence of ANA positivity among the study group than among the control group (p = 0.001). The presence of ANAs was related to the occurrence of AAS (r = 0.224, p = 0.005). Meanwhile, the positive ANAs were correlated with atherosclerosis (r = 0.167, p = 0.039), the red blood cell count (r = −0.245, p = 0.002) and C-reactive protein (r = 0.181, p = 0.042).ConclusionsOur results indicate that ANA positivity is associated with incidence of AAS, especially the incidence of intramural hematoma (IMH), suggesting that mechanisms resulting in ANA production may be involved in the development of AAS.
关键词：Antinuclear;Acute aortic syndrome;C-reactive protein