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标题：Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling
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作者：Smith B. Babiaka ; Rene Nia ; Kennedy O. Abuga 等
期刊名称：Scientific African
印刷版ISSN：2468-2276
出版年度：2020
卷号：8
页码：1-7
DOI：10.1016/j.sciaf.2020.e00423
语种：English
出版社：Elsevier
摘要：AbstractChemical investigation of the leaves ofManniophyton fulvumled to the isolation of seven flavonoid glycosides: myricetin-3-O-β-Dd-rhamnoside (1), kaempferol-3-O-β-d-rhamnoside (2), quercetin-3-O-β-d-glucoside (3), quercetin-3-O-β-d-rhamnoside (4), quercetin-3-O-β-d-galactoside (5), rutin (6)and quercetin (7). The structures of the compounds were established by spectroscopic analyses as well as by comparison with published data. Some of the compounds showed strong antioxidant activity which validates the traditional use of the plant. An attempted correlation between the computed HOMO-LUMO energies and the measured antioxidant activities was established. We have also estimated the cardiotoxicity of the compounds by calculating the predicted logarithm of the human Ether-`a-go-go Related Gene (loghERG) using the QikProp program. These purified flavonoids are new potential lead compounds for the development of antioxidant drugs.Graphical abstractDisplay Omitted
关键词：KeywordsAntioxidant and anti-inflammatoryFlavonoid glycosidesManniophyton fulvumHERGMolecular modeling