文章基本信息

标题：Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording
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作者：Fei He ; Roy Lycke ; Mehran Ganji 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：8
页码：1-15
DOI：10.1016/j.isci.2020.101387
语种：English
出版社：Elsevier
摘要：SummaryImplanted electrodes provide one of the most important neurotechniques for fundamental and translational neurosciences by permitting time-resolved electrical detection of individual neuronsin vivo. However, conventional rigid electrodes typically cannot provide stable, long-lasting recordings. Numerous interwoven biotic and abiotic factors at the tissue-electrode interface lead to short- and long-term instability of the recording performance. Making neural electrodes flexible provides a promising approach to mitigate these challenges on the implants and at the tissue-electrode interface. Here we review the recent progress of ultraflexible neural electrodes and discuss the engineering principles, the material properties, and the implantation strategies to achieve stable tissue-electrode interface and reliable unit recordings in living brains.Graphical AbstractDisplay OmittedTechniques in Neuroscience; Bioelectronics; Bioelectrical Engingeering