文章基本信息

标题：3D-Printed Composite Bone Bricks For Large Bone Tissue Applications
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作者：Evangelos Daskalakis ; Fengyuan Liu ; Anil A. Acar 等
期刊名称：MATEC Web of Conferences
电子版ISSN：2261-236X
出版年度：2020
卷号：318
页码：1-6
DOI：10.1051/matecconf/202031801009
语种：English
出版社：EDP Sciences
摘要：This study investigates the use of low cost, customizable, biodegradable, polymer-ceramic composite porous structures (bone bricks) for large bone tissue regeneration. Different ceramic materials (hydroxyapatite (HA), β-tri-calcium phosphate (TCP) and Bioglass (45S5) were mixed with poly-ε-caprolactone (PCL). Bone bricks with different material compositions were produced using an extrusion-based additive manufacturing system. Produced bone bricks were morphologically and mechanically assessed. Results allowed to establish a correlation between scaffolds architecture and material composition and scaffolds performance. Reinforced scaffolds showed improved mechanical properties. Best mechanical properties were obtained with PCL/TCP bone bricks and topologies based on 38 double zig zag filaments and 14 spirals.