文章基本信息

标题：Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
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作者：Alex H. Wrede ; Marilyn C. McNamara ; Rodger Baldwin 等
期刊名称：Global Challenges
印刷版ISSN：2056-6646
电子版ISSN：2056-6646
出版年度：2020
卷号：4
期号：7
页码：1-1
DOI：10.1002/gch2.202070071
语种：English
出版社：John Wiley & Sons, Ltd
摘要：Low‐pressure regions inside the skull can cause vapor contents in the cerebral spinal fluid to expand and collapse in traumatic brain injury (TBI). Using cell‐laden microfibers, Nicole N. Hashemi and co‐workers visually analyzed the longitudinal morphological response that astrocytes express to surrounding cavitation in vitro. Genetic analytics were conducted post‐cavitation to show drastic upregulation in TBI‐related genes. Astrocytes are known to be neurotoxic after cranial insult, and this study, described in article1900014, confirms the adverse effects that cavitation has on the astrocytic phenotype.
关键词：astrocytescavitationmicrobubblestraumatic brain injuriesultrasonics