文章基本信息

标题：Mechanochemical Synthesis of Rosuvastatin Intermediates by Liquid-Assisted Wittig Reaction
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作者：Jianbo Yan ; Chengjun Jiang
期刊名称：Open Access Library Journal
印刷版ISSN：2333-9705
电子版ISSN：2333-9721
出版年度：2020
卷号：7
期号：6
页码：1-7
DOI：10.4236/oalib.1106421
语种：English
出版社：Scientific Research Pub
摘要：Liquid-assisted Wittig reaction is used to synthesis of Rosuvastatin intermediates (1,3-Dioxane-4-acetic acid, (4R,6S)-6-[(1E)-2-[4-(4-fluorophenyl)-6- (1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,1-dimethylethyl ester). Evaluate the reaction using common green chemistry metrics: environmental factor (E-factor), and systematic investigation of the reaction has been made in order to study the various factors affecting the reaction. The E-factor of Liquid-assisted Wittig reaction is about a quarter of the traditional method. Under optimal conditions, the conversion rate can reach 99.2 and the E:Z ratio can reach 76:24.
关键词：Wittig ReactionSynthesisRosuvastatin Intermediates