文章基本信息

标题：CORDITE: The Curated CORona Drug InTERactions Database for SARS-CoV-2
本地全文：下载
作者：Roman Martin ; Hannah F. Löchel ; Marius Welzel 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：7
页码：1-7
DOI：10.1016/j.isci.2020.101297
语种：English
出版社：Elsevier
摘要：SummarySince the outbreak in 2019, researchers are trying to find effective drugs against the SARS-CoV-2 virus based onde novodrug design and drug repurposing. The former approach is very time consuming and needs extensive testing in humans, whereas drug repurposing is more promising, as the drugs have already been tested for side effects, etc. At present, there is no treatment for COVID-19 that is clinically effective, but there is a huge amount of data from studies that analyze potential drugs.We developed CORDITE to efficiently combine state-of-the-art knowledge on potential drugs and make it accessible to scientists and clinicians. The web interface also provides access to an easy-to-use API that allows a wide use for other software and applications, e.g., for meta-analysis, design of new clinical studies, or simple literature search. CORDITE is currently empowering many scientists across all continents and accelerates research in the knowledge domains of virology and drug design.Graphical AbstractDisplay OmittedHighlights•CORDITE aggregates all available knowledge on potential drugs for SARS-CoV-2•CORDITE represents the largest curated database for drugs and interactions•CORDITE makes the data accessible via a webserver and an open API•CORDITE enables easy meta-analyses, design of new clinical studies, or literature searchMedicine; Virology; Drugs; Bioinformatics; Biological Database