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标题：Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D 2R-mediated Sleep Reduction
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作者：Takato Honda ; Yohko Takata ; Yoan Cherasse 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：6
页码：1-25
DOI：10.1016/j.isci.2020.101240
语种：English
出版社：Elsevier
摘要：SummaryIndividuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated. In this study, we found that ablating the ventral medial midbrain/pons (VMP) GABAergic neurons induced mania-like behaviors in mice, including hyperactivity, anti-depressive behaviors, reduced anxiety, increased risk-taking behaviors, distractibility, and an extremely shortened sleep time. Strikingly, these mice also showed no rebound sleep after sleep deprivation, suggesting abnormal sleep homeostatic regulation. Dopamine D2receptor deficiency largely abolished the sleep reduction induced by ablating the VMP GABAergic neurons without affecting the hyperactivity and anti-depressive behaviors. Our data demonstrate that VMP GABAergic neurons are involved in the expression of mania-like behaviors, which can be segregated to the short-sleep and other phenotypes on the basis of the dopamine D2receptors.Graphical AbstractDisplay OmittedHighlights•Hyperactivity and anti-depressive behaviors are induced by loss of VMP GABA neurons•Homeostatic sleep rebound is lost together with largely shorten daily sleep•Dopamine D2receptors mediate the daytime sleep lossNeuroscience; Behavioral Neuroscience; Cellular Neuroscience