文章基本信息

标题：Serum Neurofilament Light Polypeptide is a Biomarker for Inflammation in Cerebrospinal Fluid Caused by Fine Particulate Matter
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作者：Ta-Chih Hsiao ; Jungshan Chang ; Jia-Yi Wang 等
期刊名称：Aerosol and Air Quality Research
印刷版ISSN：1680-8584
出版年度：2020
卷号：20
期号：7
页码：1665-1674
DOI：10.4209/aaqr.2019.08.0376
语种：English
出版社：Chinese Association for Aerosol Research in Taiwan
摘要：Epidemiological and toxicological evidence indicates that fine particulate matter (PM2.5, particulate matter 1 (–3) and gaseous pollutants (via high-efficiency particulate air, HEPA) for 3 and 6 months through a whole-body exposure system. According to our observations, the levels of interleukin (IL)-4, IL-10, and tumor necrosis factor (TNF)-α in the serum of the rats significantly increased (p 1, whereas that of NEFL polypeptide significantly increased (p p 1. Hence, NEFL polypeptide in serum may be a suitable biomarker for neurotoxicity caused by chronic exposure to this pollutant.
关键词：Air pollution; Central nervous system; Neurotoxicity; Oxidative stress; Particulate matter