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标题：Biogenesis of selenium nanoparticles and their anti-leukemia activity
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作者：Kasi Anu ; Sandhanasamy Devanesan ; Ramesh Prasanth 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：4
页码：2520-2526
DOI：10.1016/j.jksus.2020.04.018
语种：English
出版社：Elsevier
摘要：AbstractNanobiotechnology is an exuberant sphere of science that exhibits potential application in cancer therapy, targeted chemotherapy, molecular diagnosis and molecular imaging. Present investigation discloses green route synthesis of selenium nanoparticles leading to functionalization as anti leukemia nanomaterial. Emergence of resistance over cancer radiotherapy and chemotherapy is found to be the key factor behind the clinical treatment failure and recurrence. Selenium nanoparticles (SeNPs) with distinctive physicochemical features emerged as a novel nanocarrier and therapeutic agent with broad spectrum of medicinal properties. On the basis, biogenic technology has been proposed to synthesize selenium nanoparticles usingCassia auriculataand characterized using standard techniques. Newly synthesized selenium nanoparticles’ UV intense peak is achieved at 252 nm with crytalline surface morphology clear in SEM analysis.Cassia auriculatamediated selenium nanoparticles’ TEM analysis exhibits polydispersed with 10–20 nm. FTIR spectrum confirms the reduction of carboxyl group and capping of alkane group inCassia auriculatasynthesizes the selenium nanoparticles and its anti cancer potentiality has been explored by anti-leukemia activity usingin vitrostudies.
关键词：Nanobiotechnology;Selenium nanoparticles;Biosynthesis;Cassia auriculata;In vitro;anticancer activity